FIGURE 5.

Patient with secondary CNS lymphoma. (A) The patient received two cycles of high‐dose methotrexate to prevent rapid progression of the brain mass lesion, with a response of stable disease (pre‐infusion). (B) A computed tomography scan on day 5 showed decrease of the CNS lesion while peritumoral cerebral edema was observed. (C) To improve the cerebral edema, high‐dose steroids (dexamethasone 20 mg/day every 6 h for 2 days and tapered) were started. After the initiation of steroid, the patient's symptoms rapidly improved, and he achieved a complete metabolic response per investigator assessment on day 29. (D) The complete metabolic response persisted for 3 months after infusion (day 102). CNS, central nervous system.