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Inclisiran inhibited HUVEC cell death induced by ox-LDL. (A,B) Cell death was determined by the Hoechst 33342/PI dual-staining assay. Scale bar =50 µm. (C) Cytotoxicity was measured by LDH activity analysis. ***P<0.001 vs. the control group; #P<0.05, ##P<0.01, and ###P<0.001 vs. the ox-LDL group. HFD, high-fat diet; PI, propidium iodide; LDH, lactate dehydrogenase; ox-LDL, oxidized low-density lipoprotein; HUVEC, human umbilical vein endothelial cell.
