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. 2022 Nov;10(22):1216. doi: 10.21037/atm-22-5064

Figure 5.

Figure 5

ESR1 promotes the proliferation, migration and invasion of OC cells in vitro. (A) ESR1 protein expression in SKOV3 and HO8910 cells after ESR1 overexpression. (B,C) SKOV3 and HO8910 cell viability after ESR1 overexpression. (D) SKOV3 and HO8910 cell colony formation. Crystal violet staining; magnification, ×1. (E,F) SKOV3 and O8910 wound healing and images of monolayers were captured under an optical light microscope. Scale bars =200 µm. (G) SKOV3 and HO8910 cell invasion. Crystal violet staining; scale bars =200 µm. (H) ESR1 protein expression in SKOV3 and HO8910 cells after knockdown of ESR1. (I,J) Cell viability after knockdown of ESR1. (K-M) SKOV3 and HO8910 cell colony formation (K; crystal violet staining; magnification, ×1) and wound healing (L,M; images of monolayers were captured optical light microscope, scale bars =200 µm). (N) SKOV3 and HO8910 cell invasion. Crystal violet staining; scale bars =200 µm. Compared with vector group or shNC group, *, P<0.05. OC, ovarian cancer; ESR1, estrogen receptor 1; OD, optical density; NC, negative control.