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. 2022 Nov;10(22):1227. doi: 10.21037/atm-22-4603

Figure 6.

Figure 6

HIF1α enhances the RANKL-induced mRNA expression of osteoclast-specific genes. The expressed mRNA levels of TRAP (A,E), cathepsin K (B,F), β3-integrin (C,G), and MMP9 (D,H) were quantitatively measured using qRT-PCR with or without of different concentrations of L-mimosine and BAY-87-2243. The data are expressed as the mean ± SD of the 3 independent experiments; ##, P<0.01, vs. control group; *, P<0.05, **, P<0.01 vs. RANKL group. HIF1α, hypoxia-inducible factor 1 alpha; RANKL, receptor activator of NF-kB ligand; L-MIM, L-mimosine; TRAP, tartrate-resistant acid phosphatase; MMP9, matrix metallo-proteinase 9; qRT-PCR, quantitative real-time polymerase chain reaction; SD, standard deviation.