Table 3.

Main clinical and pathological features of ICH-affected fetuses with PLOD3 variants

Fetus	F09	F12
Sex	Female	Female
Gestation at diagnosis (weeks)	31	30
Brian imaging findings	Microcephaly, ventriculomegaly, interhemispheric cyst, porencephalic cavities, thin corpus callosum	Asymmetric bilateral ventriculomegaly, ischemic–hemorrhagic lesions in the right hemisphere
Outcome	TOP	TOP
Fetal brain examination	Important ventriculomegaly, white matter atrophy, severe microcephaly with diffuse bilateral lesions, absent or very thin corpus callosum	Asymmetric bilateral ventriculomegaly, intraparenchymal hemorrhages with cortical and subcortical ischemic foci
Skeletal X-ray examination	No sign of bone abnormality except for the absence of the 12th right rib	No sign of bone abnormality
Other autopsy anomalies	No sign of external or visceral malformation	No sign of external or visceral malformation

Abbreviation: TOP, termination of pregnancy.