TABLE 2.
Effect of maternal BMI on risk of cycle cancellation and cancellation due to poor response.
| All cycle starts (n = 152,500 cycles) |
Autologous oocytes only (n = 137,708 cycles) |
|||||
|---|---|---|---|---|---|---|
| BMI category (kg/m2) | % Cancelled | AOR | 95% CI | % Cancelled | AOR | 95% CI |
| All cancellations | ||||||
| Underweight (<18.5) | 9.2 | 1.05 | 0.95–1.17 | 9.4 | 1.04 | 0.93–1.16 |
| Normal weight (18.5–24.9) | 9.3 | 1.00 | Reference | 9.6 | 1.00 | Reference |
| Overweight (25.0–29.9) | 9.8 | 1.05 | 1.01–1.10 | 10.3 | 1.06 | 1.02–1.11 |
| Obese, class I (30.0–34.9) | 10.5 | 1.16 | 1.10–1.23 | 10.8 | 1.17 | 1.10–1.25 |
| Obese, class II (35.0–39.9) | 11.2 | 1.29 | 1.19–1.39 | 11.6 | 1.31 | 1.20–1.42 |
| Obese, class III | ||||||
| 40.0–44.9 | 12.1 | 1.43 | 1.26–1.62 | 12.5 | 1.46 | 1.29–1.66 |
| 45.0–49.9 | 10.4 | 1.22 | 0.97–1.53 | 11.2 | 1.30 | 1.03–1.64 |
| ≥50.0 | 15.5 | 1.92 | 1.39–2.65 | 16.1 | 1.97 | 1.42–2.74 |
| Cancellations due to low response | ||||||
| Underweight (<18.5) | 62.8 | 0.78 | 0.63–0.97 | 65.4 | 0.80 | 0.63–1.01 |
| Normal weight (18.5–24.9) | 68.9 | 1.00 | Reference | 71.5 | 1.00 | Reference |
| Overweight (25.0–29.9) | 72.9 | 1.28 | 1.17–1.41 | 75.4 | 1.31 | 1.19–1.45 |
| Obese, class I (30.0–34.9) | 69.1 | 1.12 | 1.00–1.27 | 71.6 | 1.16 | 1.02–1.32 |
| Obese, class II (35.0–39.9) | 73.1 | 1.45 | 1.22–1.72 | 75.5 | 1.52 | 1.26–1.82 |
| Obese, class III | ||||||
| 40.0–44.9 | 73.9 | 1.59 | 1.22–2.09 | 76.2 | 1.70 | 1.27–2.26 |
| 45.0–49.9 | 85.7 | 3.46 | 1.85–6.49 | 86.7 | 3.48 | 1.81–6.70 |
| ≥50.0 | 77.8 | 1.95 | 0.94–4.02 | 77.3 | 1.81 | 0.87–3.77 |
Note: Models were adjusted for woman's age, race/ethnicity, height, nulligravidity, and infertility diagnoses. All tests of equality of AORs within each outcome were significant at P<.0001. Adapted from: Luke B, Brown MB, Missmer SA, Bukulmez O, Leach R, Stern JE. The effect of increasing obesity on the response to and outcome of assisted reproductive technology: a national study. Fertil Steril 2011; 96:820–5. AOR = adjusted odds ratio; BMI = body mass index; CI = confidence interval.
Luke. Obesity and race and female fecundity. Fertil Steril 2017.