TABLE 4.

Effect of BMI on failure to achieve a clinical intrauterine pregnancy and a live birth.

	Autologous oocytes
	Fresh embryos						Thawed embryos
	Not pregnant (n = 101,531)			Fetal loss/stillborn (n = 42,699)			Not pregnant (n = 22,643)			Fetal loss/stillborn (n = 8,649)
BMI category (kg/m²)	%	AOR	95% CI	%	AOR	95% CI	%	AOR	95% CI	%	AOR	95% CI
Underweight (<18.5)	57.2	1.07	0.99–1.16	15.3	0.98	0.83–1.15	59.5	0.98	0.84–1.14	21.3	1.18	0.87–1.59
Normal weight (18.5–24.9)	57.0	1.00	Reference	16.6	1.00	Reference	61.6	1.00	Reference	19.4	1.00	Reference
Overweight (25.0–29.9)	58.0	1.03	1.00–1.06	18.5	1.10	1.03–1.17	60.7	0.95	0.89–1.02	21.1	1.05	0.93–1.20
Obese, class I (30.0–34.9)	59.4	1.14	1.09–1.19	20.7	1.25	1.15–1.36	63.4	1.09	0.99–1.19	27.4	1.51	1.27–1.79
Obese, class II (35.0–39.9) Obese, class III	60.8	1.26	1.18–1.34	21.4	1.34	1.18–1.51	63.0	1.06	0.93–1.22	32.7	1.83	1.44–2.32
40.0–44.9	63.0	1.41	1.27–1.57	22.6	1.39	1.14–1.69	65.6	1.18	0.93–1.48	30.7	1.78	1.18–2.69
45.0–49.9	62.4	1.40	1.17–1.67	26.0	1.67	1.21–2.31	71.1	1.60	1.06–2.41	30.3	1.80	0.85–3.83
≥50.0	64.5	1.53	1.13–2.06	31.4	2.29	1.37–3.83	57.6	0.77	0.39–1.55	14.3	0.54	0.12–2.43
	Donor oocytes
	Fresh embryos						Thawed embryos
	Not pregnant (n = 9,366)			Fetal loss/stillborn (n = 5,812)			Not pregnant (n = 3,975)			Fetal loss/stillborn (n = 1,565)
Underweight (<18.5)	35.2	0.96	0.72–1.27	12.3	1.00	0.59–1.69	63.0	1.11	0.72–1.72	26.5	1.72	0.77–3.82
Normal weight (18.5–24.9)	37.0	1.00	Reference	12.5	1.00	Reference	59.9	1.00	Reference	18.9	1.00	Reference
Overweight (25.0–29.9)	38.0	1.00	0.90–1.11	15.4	1.26	1.06–1.51	60.9	1.03	0.88–1.21	22.3	1.23	0.91–1.66
Obese, class I (30.0–34.9)	42.0	1.16	0.99–1.35	17.9	1.51	1.16–1.96	60.3	1.00	0.79–1.25	27.2	1.61	1.07–2.43
Obese, class II (35.0–39.9) Obese, class III	41.0	1.13	0.89–1.42	17.7	1.49	1.01–2.20	58.8	0.92	0.67–1.26	19.2	1.03	0.55–1.90
40.0–44.9	37.0	0.98	0.65–1.47	23.4	2.18	1.21–3.94	72.3	1.76	1.01–3.06	17.6	0.87	0.24–3.10
45.0–49.9	37.5	0.97	0.51–1.86	12.0	0.94	0.28–3.16	77.8	2.26	0.73–6.97	–	–	–
≥50.0	36.4	0.76	0.22–2.64	28.3	2.44	0.46–12.91	100.0	–	–	–	–	–

Note: Models were adjusted for woman's age, race/ethnicity, height, nulligravidity, infertility diagnoses, and number of embryos transferred. Adapted from: Luke B, Brown MB, Missmer SA, Bukulmez O, Leach R, Stern JE. The effect of increasing obesity on the response to and outcome of assisted reproductive technology: a national study. Fertil Steril 2011; 96:820–5. Abbreviations as in Table 2.

Luke. Obesity and race and female fecundity. Fertil Steril 2017.