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. 2022 Nov 7;23(3):320–330. doi: 10.1016/S1473-3099(22)00662-4

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Elsevier has created a Monkeypox Information Center (https://www.elsevier.com/connect/monkeypox-information-center) in response to the declared public health emergency of international concern, with free information in English on the monkeypox virus. The Monkeypox Information Center is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its monkeypox related research that is available on the Monkeypox Information Center - including this research content - immediately available in publicly funded repositories, with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the Monkeypox Information Center remains active.

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Deep immune profiling of CD8+ T cells

(A) Uniform Manifold Approximation and Projection (UMAP) plot shows the 2D spatial distribution of CD8+ T cells from healthy donors (n=4) and patients with monkeypox (n=5) embedded with FlowSOM clusters. The colour of each cluster corresponds to the colour of the heatmap in figure 4B. (B) Heatmap of the median marker intensities of the lineage markers across the 25 cell populations obtained with FlowSOM algorithm. The colours of cluster identification column correspond to the colours used to label the UMAP plot clusters. The colour in the heatmap is referred to the median of the arcsinh marker expression (0 to 1 scale) calculated over cells from all the samples. Light grey bar along the rows (clusters) and values in brackets indicate the relative sizes of clusters. (C) Relative cell proportion of different clusters between healthy donors (n=4), and Monkeypox patients (n=5). The central bar represents the mean (SD). CD=cluster differentiation. CXCR=chemokine receptors. TEMRA=T effector memory re-expressing CD45RA.

Deep immune profiling of CD8+ T cells

(A) Uniform Manifold Approximation and Projection (UMAP) plot shows the 2D spatial distribution of CD8+ T cells from healthy donors (n=4) and patients with monkeypox (n=5) embedded with FlowSOM clusters. The colour of each cluster corresponds to the colour of the heatmap in figure 4B. (B) Heatmap of the median marker intensities of the lineage markers across the 25 cell populations obtained with FlowSOM algorithm. The colours of cluster identification column correspond to the colours used to label the UMAP plot clusters. The colour in the heatmap is referred to the median of the arcsinh marker expression (0 to 1 scale) calculated over cells from all the samples. Light grey bar along the rows (clusters) and values in brackets indicate the relative sizes of clusters. (C) Relative cell proportion of different clusters between healthy donors (n=4), and Monkeypox patients (n=5). The central bar represents the mean (SD). CD=cluster differentiation. CXCR=chemokine receptors. TEMRA=T effector memory re-expressing CD45RA.