Table 2.
Clinical characteristics of patients with unique adrenal histology
| Histology | MAPN | Double APN | APA with MAPN | NFA | NFA with MAPM | |
|---|---|---|---|---|---|---|
| Study ID | ELA50 | ELA146 | ELA130 | ELA160 | ELA120 | ELA128 |
| Basic clinical characteristics | ||||||
| Age | 15 | 22 | 28 | 25 | 34 | 30 |
| Sex | Woman | Man | Woman | Woman | Woman | Woman |
| Race | Unknown | White | Asian | White | Unknown | White |
| Blood pressure (mmHg) | 138/77 | 136/94 | 138/92 | 140/90 | NA | 136/62 |
| Number of antihypertensive medications | 2 | 4 | 1 | 3 | 3 | 5 |
| Serum potassium (mEq/L) | 2.3 | 3.8 | 3.9 | 3.0 | 2.9 | 3.0 |
| Potassium supplementation | No | Yes | No | Yes | Yes | Yes |
| PAC (ng/dL) | 25.1 | 36.0 | 11.0 | 30.8 | 17.0 | 53.8 |
| PRA (ng/mL/h) | NA | 0.6 | 0.6 | 0.7 | 0.6 | 2.8 |
| DRC (mU/L) | 0.8 | NA | NA | NA | NA | NA |
| Serum cortisol post-1-mg DST (µg/dL) | NA | 1.6 | NA | 10.7 | NA | NA |
| CT findings of adrenal glands | Hyperplasia | Bilateral thickening | Left adrenal mass (5 mm) | Bilateral adrenal mass (right 20 mm, left 14 mm) | Left adrenal mass (16 mm) | Left adrenal mass (10 mm) |
| AVS | ||||||
| Cosyntropin stimulation | No | Yes | Yes | Yes | Yes | Yes |
| Right AV aldosterone (ng/dL) | 188.5 | 4250 | 470 | 13 500 | 462 | 947 |
| Right AV cortisol (µg/dL) | 16.5 | 236 | 620 | 1101 | 1020 | 730 |
| Left AV aldosterone (ng/dL) | 3510 | 39 400 | 2280 | 660 | 8810 | 11 411 |
| Left AV cortisol (µg/dL) | 42.5 | 586 | 390 | 372 | 462 | 880 |
| IVC aldosterone (ng/dL) | 23.6 | 314 | 232 | 66.1 | 129 | 57 |
| IVC cortisol (µg/dL) | 5.0 | 12 | 26 | 25.9 | 25 | 24 |
| Selectivity index (right) | 3.3 | 19.7 | 23.8 | 42.5 | 40.8 | 30.4 |
| Selectivity index (left) | 8.5 | 48.8 | 15.0 | 14.4 | 18.5 | 36.7 |
| A/C (right) | 11.4 | 18.0 | 0.8 | 12.3 | 0.5 | 1.3 |
| A/C (left) | 82.6 | 67.2 | 5.8 | 1.8 | 19.1 | 13.0 |
| A/C (IVC) | 4.7 | 26.2 | 8.9 | 2.6 | 5.2 | 2.4 |
| Lateralized ratio | 7.2 | 3.7 | 7.7 | 6.9 | 42.1 | 10.0 |
| Contralateral ratio | 2.4 | 0.7 | 0.1 | 0.7 | 0.1 | 0.5 |
| Side of aldosterone excess by AVS | Left | Left | Left | Right | Left | Left |
| Side of adrenalectomy | Left | Left | Left | Right | Left | Left |
| Postsurgical clinical data | ||||||
| Follow-up timing (months) | 6-12 | 3 | 2 | 1 | NA | 0.5 |
| Blood pressure (mmHg) | 122/80 | 131/91 | NA | 132/92 | NA | 152/94 |
| Number of antihypertensive medications | 1 | 3 | 0 | 0 | NA | 1 |
| Serum potassium (mEq/L) | 4.6 | 4.5 | 4.3 | 4.0 | NA | 4.7 |
| PAC (ng/dL) | 10.2 | NAa | NA | 11.7 | NA | NA |
| PRA (ng/mL/h) | NA | NA | NA | NA | NA | NA |
| DRC (mU/L) | 16.2 | NA | NA | NA | NA | NA |
| DRC (pg/mL) | NA | NA | NA | 11.3 | NA | NA |
Abbreviations: A/C, aldosterone/cortisol; APA, aldosterone-producing adenoma; AV, adrenal vein; AVS, adrenal venous sampling; CT, computed tomography; DRC, direct renin concentration; DST, dexamethasone suppression test; IVC, inferior vena cava; MAPM, multiple aldosterone-producing micronodules; MAPN, multiple aldosterone-producing nodules; NA, not available; NFA, nonfunctioning adenoma; PAC, plasma aldosterone concentration; PRA, plasma renin activity.
a Postsurgical PAC on day 1 after surgery was 7.1 ng/dL.