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. 2022 Dec 19;9:57. doi: 10.1186/s40580-022-00349-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Anti-fibrotic properties of EVs. a The fluorescence-based immunocytochemistry of fibronectin expression of TGF-β induced fibrosis condition in HK2 cells. b Western blot analysis for representative fibrosis markers after EVs treatments in fibrosis induced-HK2 cells. c Quantification data for N-cadherin and fibronectin expression from Western blot analysis (analysis with Image J, values are presented as mean ± SD (n = 3) and statistical significance was obtained with one-way analysis of ANOVA with Tukey’s multiple comparison post-test (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001))