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. 2022 Sep 30;116(6):1553–1564. doi: 10.1093/ajcn/nqac283

FIGURE 4.

FIGURE 4

Hispanic subjects within the low-income stratification show a stronger association with supplemental folic acid intake compared with non-Hispanic White subjects. (A) Folate distribution by source within lower-income subjects (annual income <$75,000/y) stratified by Hispanic (n = 150) and non-Hispanic White (n = 77) subjects. Hispanic subjects were found to take in higher concentrations of folate from food sources, whereas non-Hispanic White subjects take in higher concentrations of folate from supplemental sources. (B) Regression results were associated with supplemental folic acid intake in all lower-income subjects (n = 257; left panel) compared with regression results further stratified by Hispanic subjects only (middle panel) and non-Hispanic White subjects (right panel). The hatched line represents FDR <0.05. Bolded points positioned above the hatched line represent significant DMPs. (C) Table demonstrating median folate values in lower-income subjects further stratified by Hispanic ethnicity. DFE, dietary folate equivalent; DMP, differentially methylated probe; FDR, false discovery rate.