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. 2022 Oct 17;116(6):1507–1514. doi: 10.1093/ajcn/nqac207

TABLE 2.

The association between timing of alcohol intake with respect to meals and risk of type 2 diabetes1

No It varies Yes P-trend
 Cases, n (%) 2328 (3.7) 3033 (2.7) 3237 (2.4)
 Model 1, HR (95% CI) 1 (reference) 0.92 (0.87, 0.97) 0.88 (0.83, 0.93) <0.001
 Model 1 + alcohol consumption, HR (95% CI) 1 (reference) 0.93 (0.88, 0.98) 0.86 (0.82, 0.91) <0.001
 Model 1 + frequency of drinking, HR (95% CI) 1 (reference) 0.94 (0.89, 0.99) 0.89 (0.84, 0.94) <0.001
 Model 2, HR (95% CI) 1 (reference) 0.94 (0.89, 0.99) 0.88 (0.83, 0.93) <0.001
1

Model 1 adjusted for age, sex, race, BMI, physical activity, smoking, healthy diet score, Townsend deprivation index, hypertension, high cholesterol, and family history of diabetes. Model 2 further adjusted for alcohol intake level and frequency of drinking on the basis of model 1.