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. 2022 Dec 5;10:998013. doi: 10.3389/fchem.2022.998013

FIGURE 4.

FIGURE 4

Combination treatment of YH29407 and aPD-1 enhanced T cell activation, particularly effector T cells and helper T cells. Infiltrated CD3+ T cells (A) and CD8+ T cells (B) to the tumor were significantly enhanced in the YH29407+aPD-1 group compared to the other groups. (C) Total T cells, effector T cells, helper T cells, and ki-67 + Tc cells were significantly increased in the YH29407+aPD-1 group. However, PD-1+ Tc cells and Treg were decreased in the YH29407+aPD-1 group compared to the control and other groups. Immune cell depletion affected survival (D) and tumor growth in MC38 tumor-bearing mice (E). Statistical significance between groups was calculated using two-way ANOVA followed by Tukey’s multiple comparisons test or student’s t-test (*p < 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001). Tc, cytotoxic T cell; Treg, regulatory T cell; ANOVA, analysis of variance.