表 3.
RA各亚型间免疫学指标比较
Comparison of immunologic parameters of the four subtypes
| Items | Small joint subtype (n=74) | Total joint subtype (n=154) | Systemic subtype (n=100) | Overlapping subtype (n=83) | χ 2 | P value |
| The variables are denoted by n(%).γG, γ globulin; TP, total protein; IgA, immunoglobulin A; IgG, immunoglobulin G; IgM, immunoglobulin M; C3, complement 3; RF, rheumatoid factors; CCP, cyclic citrullinated polypeptide; APF, antiperinuclear factor; MCV, mutant citrullinated vimentin antibody; GPI, glucose 6-phosphate isomerase antibody; ANA, antinuclear antibodies. | ||||||
| γG/TP elevation/%, M (P25, P75) | 17.40 (14.90，20.80) | 20.50 (16.45，23.13) | 19.90 (17.10，23.20) | 22.25 (17.85，25.38) | 12.892 | 0.005 |
| IgA elevation | 8 (11.1) | 25 (16.9) | 21 (22.1) | 13 (15.7) | 3.651 | 0.302 |
| IgG elevation | 6 (8.3) | 35 (23.6) | 20 (21.1) | 21 (25.3) | 8.597 | 0.035 |
| IgM elevation | 1 (1.4) | 4 (2.7) | 4 (4.2) | 6 (7.2) | 4.379 | 0.223 |
| C3 reduction | 17 (23.6) | 16 (10.9) | 15 (15.8) | 21 (25.3) | 10.060 | 0.018 |
| RF-IgM | 62 (83.8) | 108 (70.6) | 74 (75.5) | 64 (77.1) | 4.855 | 0.183 |
| RF-IgA | 15 (41.7) | 17 (22.4) | 9 (16.1) | 9 (20.9) | 8.486 | 0.037 |
| RF-IgG | 32 (45.1) | 36 (24.8) | 33 (33.3) | 28 (34.6) | 9.182 | 0.027 |
| anti-CCP | 66 (90.4) | 125 (82.8) | 87 (87.9) | 72 (87.8) | 3.008 | 0.39 |
| APF | 50 (70.4) | 89 (61.4) | 69 (69.7) | 50 (61.7) | 3.097 | 0.377 |
| anti-MCV | 28 (75.7) | 47 (64.4) | 33 (78.6) | 27 (67.5) | 3.263 | 0.353 |
| GPI | 25 (35.2) | 56 (38.6) | 46 (46.5) | 29 (35.8) | 3.067 | 0.381 |
| ANA | 24 (33.8) | 31 (21.2) | 34 (34.7) | 37 (44.6) | 14.306 | 0.003 |
| Homogeneous type ANA | 23 (32.4) | 57 (39.0) | 36 (36.7) | 26 (31.3) | 1.786 | 0.618 |
| Spotting type ANA | 20 (28.2) | 31 (21.2) | 26 (26.5) | 34 (41.0) | 10.364 | 0.016 |