表 2.
唇腺病理阳性与阴性pSS患者免疫指标比较[n (%)]
Comparison of immune indicators between positive-pSS and negative-pSS patients [n (%)]
| Variables | Positive-pSS (n=104) | Negative-pSS (n=113) | Statistics | P |
| pSS, primary Sjögren’s syndrome; ANA, antinuclear antibody; Anti-SSA, anti-Sjogren’s syndrome antigen A antibody; Anti-SSB, anti-Sjogren’s syndrome antigen B antibody; AMA-M2, anti-mitochondrial antibody-M2; Anti-CENP-B, anti-centromere protein B antibody; Anti-RNP, anti-ribonucleo- protein antibody; Anti-dsDNA，anti-double stranded DNA antibody; Anti-CCP, anti-cyclic citrullinated peptide antibody; RF, rheumatoid factor; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; NA, not applicable. | ||||
| ANA seropositive | 101 (97.1) | 111 (98.2) | 0.009 | 0.925 |
| ANA titer = 1 ∶100 | 6 (5.8) | 14 (12.4) | 2.837 | 0.092 |
| ANA titer = 1 ∶320 | 9 (8.7) | 20 (17.7) | 3.723 | 0.054 |
| ANA titer = 1 ∶1 000 | 19 (18.3) | 26 (23.0) | 0.740 | 0.390 |
| ANA titer ≥ 1 ∶3 200 | 67 (64.4) | 51 (45.1) | 8.123 | 0.004 |
| Anti-SSA | 86 (82.7) | 98 (86.7) | 0.683 | 0.408 |
| Anti-Ro-52 | 87 (83.7) | 90 (79.6) | 0.579 | 0.447 |
| Anti-SSB | 48 (46.2) | 34 (30.1) | 5.946 | 0.015 |
| AMA-M2 | 8 (7.7) | 15 (13.3) | 1.781 | 0.182 |
| Anti-CENP-B | 8 (7.7) | 10 (8.9) | 0.095 | 0.757 |
| Anti-RNP/Sm | 11 (10.6) | 12 (10.6) | 0.000 | 0.992 |
| Anti-dsDNA | 0 | 1 (0.9) | ||
| Anti-CCP | 1/40 (2.5) | 2/43 (4.7) | >0.999 | |
| IgG>1 600 mg/dL | 71/96 (74.0) | 60/99 (60.6) | 3.941 | 0.047 |
| IgA>450 mg/dL | 18/96 (18.8) | 13/99 (13.1) | 1.151 | 0.283 |
| IgM>270 mg/dL | 9/96 (9.4) | 7/99 (7.1) | 0.344 | 0.558 |
| C3 < 80 mg/dL | 43/96 (44.8) | 37/97 (38.1) | 0.878 | 0.349 |
| C4 < 16 mg/dL | 36/96 (37.5) | 33/97 (34.0) | 0.254 | 0.614 |
| RF seropositive | 70/96 (72.9) | 56/97 (57.7) | 4.909 | 0.027 |
| ESR>20 mm/h | 48/83 (57.8) | 31/82 (37.8) | 6.629 | 0.010 |
| CRP>0.8 mg/dL | 9/94 (9.6) | 5/97 (5.2) | 1.373 | 0.241 |