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. 2022 Oct 20;63(12):100304. doi: 10.1016/j.jlr.2022.100304

Fig. 5.

Fig. 5

LC-MS/MS analyses of PLs and SLs in the GL261 mouse glioma and the contralateral healthy control brain tissue. A: Volcano plot summarizes the paired t-test comparisons of tumoral PLs and SLs to those in the contralateral control brain tissue (N = 8), showing lipid species of statistically significant (P < 0.05, −log10(P) >1.301; horizontal dash bar) with more than two FCs (i.e., log2(FC) >1 or <−1) in difference. Lipid species marked in red indicates significant increase in tumor, and lipid species marked in blue indicates significant decrease in tumor. Vertical dashed lines denote the log2(FC) cutoff at 1.322 (right, i.e., FC = 2.5) or −1.322 (left; FC = 0.4). Summary of paired t-test (mean ± SEM) in B: total PCs; C: total LPCs; D: total PEs; E: total LPEs; F: total PIs; G: total SMs; H: total Cers; and I: total lipids, between the control brain tissue (control; blue bar) and tumor tissue (tumor; red bar). N = 8 each. ∗P < 0.05; ∗∗P < 0.01. C16:0: Cer d18:1/16:0; C18:0: Cer d18:1/18:0; and SM16:0: SM d18:1/16:0.