Table 2.
Accuracy of the Xpert MTB/RIF Ultra Assay for Diagnosing Pulmonary Tuberculosis in Children by Number of Oral Swab Specimens
| Swab Specimen Type | Any Oral Swab Specimen | 1 Oral Swab Specimen | 2 Oral Swab Specimens | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Participants, No.a | Sensitivity (95% CI), % | Specificity (95% CI), % | Participants, No.a | Sensitivity (95% CI), % | Specificity (95% CI), % | Participants, No.a | Sensitivity (95% CI), % | Specificity (95% CI), % | |
| Reference standard: confirmed and unconfirmed pulmonary tuberculosis combined | |||||||||
| Tongue and buccal combined | 288 | 8.5 (5.7–12.7) | 100 (91.6–100) | 285 | 8.2 (5.4–12.3) | 100 (91.4–100) | 164 | 10.3 (6.4–16.4) | 100 (83.2–100) |
| Reference standard: confirmed pulmonary tuberculosis only | |||||||||
| Tongue and buccal combined | 132 | 22.2 (14.9–31.9) | 100 (91.6–100) | 130 | 21.4 (14.1–31.0) | 100 (91.4–100) | 75 | 25.0 (15.5–37.7) | 100 (83.2–100) |
| Buccal only | 54 | 27.3 (15.1–44.2) | 100 (84.5–100) | 54 | 27.3 (15.1–44.2) | 100 (84.5–100) | 34 | 25.0 (12.0–44.9) | 100 (72.3–100) |
| Tongue only | 78 | 19.3 (11.1–31.3) | 100 (84.5–100) | 76 | 17.9 (10.0–29.8) | 100 (83.9–100) | 41 | 25.0 (13.3–42.1) | 100 (70.1–100) |
Abbreviation: CI, confidence interval.
a
Excluding participants with invalid Xpert TB/RIF Ultra assay results.