Table 3.
Accuracy of the Xpert MTB/RIF Ultra Assay With 1 or 2 Oral Swab Specimens for Diagnosing Pulmonary Tuberculosis in Children: Subgroup Analyses
| Subgroup | Participants, No.a | Sensitivity (95% CI), %b | Specificity (95% CI), %b |
|---|---|---|---|
| HIV positive | 19 | 33.3 (15.2–58.3) | 100 (51.0–100) |
| HIV negative | 112 | 20.3 (17.7–30.8) | 100 (90.8–100) |
| Malnutrition | 42 | 27.3 (15.1–44.2) | 100 (70.1–100) |
| Malnutrition and/or stunting | 66 | 25.5 (16.6–38.9) | 100 (79.6–100) |
| Age <12 m | 26 | 22.2 (9.0–45.2) | 100 (67.6–100) |
| Age <60 m | 81 | 18.2 (10.2–30.3) | 100 (87.1–100) |
| Age >60 m | 51 | 28.6 (16.3–45.1) | 100 (80.6–100) |
| PurFlock swabs only | 82 | 24.1 (14.6–37.0) | 100 (88.0–100) |
| COPAN FLOQSwabs only | 50 | 19.4 (9.8–35.0) | 100 (78.5–100) |
Abbreviations: CI, confidence interval; HIV, human immunodeficiency virus.
a
Excluding participants with invalid Xpert MTB/RIF Ultra assay results.
b
All results are given for tongue and buccal swab specimens combined.