Table 2.

Multiple linear regression model with the severity of neuropsychiatric symptoms as a dependent variable and cerebrospinal fluid cortisol and dehydroepiandrosterone sulfate as independent variables

Model 1: Independent variables: CSF cortisol, CSF DHEAS, CSF AD pathology, sex, age, APOEε4 status
			95.0% confidence interval forB		Partial regression
Variable	B	Sig.	Lower bound	Upper bound		VIF
CSF cortisol	.085	.005	.027	.144	.277	1.189
CSF DHEAS	−1.060	.365	−3.370	1.251	−.086	1.123
CSF AD pathology	2.765	.022	.414	5.117	.222	1.129
Sex	.508	.599	−1.406	2.421	.050	1.307
Age	−.009	.893	−.141	.123	−.013	1.686
APOEε4 status	.213	.853	−2.062	2.488	.018	1.517
Model 2: Independent variables: CSF cortisol, CSF DHEAS, CSF AD pathology, sex, age, APOEε4, BMI, use of psychotropic medication
			95.0% confidence interval forB		Partial regression
Variable	B	Sig.	Lower bound	Upper bound		VIF
CSF cortisol	.080	.008	.021	.139	.283	1.216
CSF DHEAS	−1.133	.332	−3.443	1.176	−.105	1.126
CSF AD pathology	2.225	.083	−.296	4.746	.187	1.945
Sex	.499	.605	−1.411	2.409	.056	1.129
Age	−.045	.541	−.190	.101	−.066	1.589
APOEε4 status	.074	.949	−2.209	2.357	.007	1.534
Baseline cognitive impairment	1.468	.246	−1.032	3.968	.126	1.913
Model3: Independent variables: CSF cortisol, CSF DHEAS, CSF AD pathology, sex, age, APOEε4, BMI, use of psychotropic medication
			95.0% confidence interval forB		Partial regression
Variable	B	Sig.	Lower bound	Upper bound		VIF
CSF cortisol	.062	.039	.003	.121	.225	1.325
CSF DHEAS	−1.343	.238	−3.590	.904	−.129	1.148
CSF AD pathology	3.779	.002	1.377	6.181	.325	1.883
Sex	1.200	.213	−.703	3.103	.136	1.209
Age	−.060	.365	−.191	.071	−.099	1.405
APOEε4 status	−.407	.719	−2.645	1.831	−.040	1.568
BMI	.137	.202	−.075	.349	.140	1.221
Use of psychotropic medication	2.958	.009	.757	5.159	.281	1.273

AD Alzheimer’s disease, APOE the apolipoprotein E, BMI body mass index, CSF cerebrospinal fluid, DHEAS dehydroepiandrosterone sulfate, VIF variance inflation factor