Table 3.
Multivariate analysis of covariance (MANCOVA) with the twelve Neuropsychiatric Inventory severity subscores as dependent variables and with CSF cortisol, CSF DHEAS, Alzheimer’s disease CSF pathology, APOE status, sex, and age as independent variables
| Effect | Pillai’s trace | F | Error df | Sig. | Partial eta squared | |
| Intercept | .078 | .481b | 68.000 | .919 | .078 | |
| CSF cortisol | .257 | 1.962b | 68.000 | .042 | .257 | |
| DHEAS | .111 | .705b | 68.000 | .741 | .111 | |
| Age | .081 | .501b | 68.000 | .907 | .081 | |
| Sex | .284 | 2.249b | 68.000 | .018 | .284 | |
| AD pathology status | .342 | 2.951b | 68.000 | .002 | .342 | |
| APOEε4 status | .219 | 1.588b | 68.000 | .116 | .219 | |
| Sex * CSF AD pathology | .233 | 1.723b | 68.000 | .081 | .233 | |
| Sex * APOEε4 status | .229 | 1.682b | 68.000 | .090 | .229 | |
| CSF AD pathology * APOEε4 status | .219 | 1.585b | 68.000 | .117 | .219 | |
| Sex * CSF AD pathology * APOEε4 status | .196 | 1.377b | 68.000 | .198 | .196 | |
| Tests of between-subject effects | ||||||
| Variable | Dependent variable | Type III sum of squares | Mean square | F | Sig. | Partial eta squared |
| CSF cortisol | Delusions | .027 | .027 | .235 | .630 | .003 |
| Hallucinations | .037 | .037 | .795 | .375 | .010 | |
| Agitation/aggression | .092 | .092 | .202 | .654 | .003 | |
| Depression/dysphoria | 5.691 | 5.691 | 9.093 | .003 | .103 | |
| Anxiety | 8.783 | 8.783 | 12.210 | .001 | .134 | |
| Elation/euphoria | .054 | .054 | .600 | .441 | .008 | |
| Apathy/indifference | 9.300 | 9.300 | 12.731 | .001 | .139 | |
| Disinhibition | .087 | .087 | .594 | .443 | .007 | |
| Irritability/lability | 1.599 | 1.599 | 3.105 | .082 | .038 | |
| Motor disturbance | .213 | .213 | 1.257 | .266 | .016 | |
| Nightime behaviors | .871 | .871 | 2.363 | .128 | .029 | |
| Appetite/eating | .739 | .739 | 1.830 | .180 | .023 | |
| AD pathology | Delusions | .315 | .315 | 2.698 | .104 | .033 |
| Hallucinations | .049 | .049 | 1.050 | .309 | .013 | |
| Agitation/aggression | 2.085 | 2.085 | 4.586 | .035 | .055 | |
| Depression/dysphoria | .809 | .809 | 1.293 | .259 | .016 | |
| Anxiety | 2.297 | 2.297 | 3.194 | .078 | .039 | |
| Elation/euphoria | .039 | .039 | .430 | .514 | .005 | |
| Apathy/indifference | 4.911 | 4.911 | 6.722 | .011 | .078 | |
| Disinhibition | .336 | .336 | 2.283 | .135 | .028 | |
| Irritability/lability | 1.426 | 1.426 | 2.769 | .100 | .034 | |
| Motor disturbance | .910 | .910 | 5.366 | .023 | .064 | |
| Nighttime behaviors | .014 | .014 | .038 | .846 | .000 | |
| Appetite/eating | .002 | .002 | .005 | .945 | .000 | |
AD Alzheimer’s disease, APOE the apolipoprotein E, CSF cerebrospinal fluid, DHEAS dehydroepiandrosterone sulfate