Table 1.
Comparison of the clinical profiles of participants experiencing (or not) a functional decline at 6 months of follow-up
| Characteristics | Overall (N = 137) | Decliners (N = 94) | Non-decliners (N = 43) | p-value |
|---|---|---|---|---|
| Age years | 81.00 (7.00) | 82.00 (5.00) | 80.00 (6.00) | p = .006 |
| Sex, N (% of Women) | 75 (54.74) | 50 (53.19) | 25 (58.14) | p = .589 |
| Education Level | p = .421 | |||
| Secondary school or lower | 77 (56.20) | 55 (58.51) | 22 (51.16) | |
| Higher than secondary school | 60 (43.80) | 39 (41.49) | 21 (48.84) | |
| Cognitive Disorders | p < .001 | |||
| Absence of CD | 36 (26.28) | 16 (17.02) | 20 (46.51) | |
| Non-neuro-degenerative CD | 33 (24.09) | 20 (21.28) | 13 (30.23) | |
| Neuro-degenerative CD | 68 (49.63) | 58 (61.70) | 10 (23.26) | |
| Number of Medication, | 7.00 (6.00) | 7.50 (5.00) | 6.00 (6.00) | p = .046 |
| Frailty Fried score (total score/5) | 2.00 (3.00) | 2.00 (2.00) | 1.00 (3.00) | p = .009 |
| MMSE score (total score/30) | 26.00 (5.00) | 25.00 (6.00) | 27.00 (5.00) | p = .002 |
| Functional Status at baseline | ||||
| b-ADL (total score/24), | 7.00 (2.00) | 7.00 (3.00) | 6.00 (1.00) | p = .001 |
| i-ADL, (total score/27), | 15.00 (8.00) | 16.00 (8.00) | 13.00 (8.00) | p = .012 |
| Executive Function at Inclusion | ||||
| Stroop (number of errors) | 4.00 (8.00) | 5.00 (9.00) | 2.00 (4.00) | p < .001 |
| Lexical fluency (total score) | 13.00 (9.00) | 11.00 (8.00) | 15.00 (12.00) | p = .001 |
| Semantic fluency (total score) | 20.00 (10.00) | 17.00 (10.00) | 23.00 (8.00) | p < .001 |
| TMT-B (time in seconds) | 249.00 (276.00) | 263.00 (318.25) | 178.00 (195.00) | p = .001 |
| Zoo profile (composite score) | 2.00 (2.00) | 2.0 (2.00) | 2.0 (1.00) | p = .071 |
| 2-Back (total Score/16) | 10.00 (6.00) | 9.50 (6.00) | 11.00 (6.00) | p = .108 |
Numerical data are expressed as the median and interquartile range. Categorical data are expressed by their absolute number and their percentage. Significant independent Whitney-Mann U Test or Chi-squared tests in bold
M median, CD cognitive disorders, MMSE Mini Mental State Examination, TMT-B Trail Making Task B, b-ADL basic activities of daily living, i-ADL instrumental activities of daily living