Table 2.
Associations between blood lipid biomarkers and 10-year CVD incidence in the total study population (n = 2020)
| 10-year CVD incidence | ||||||
|---|---|---|---|---|---|---|
| RR | 95%CI | P value | Adj. R2 | Harrell’s C | cNRI | |
| TC, mg/dL | 1.003 | 0.999, 1.007 | 0.111 | 17.4% | 0.205 | 10.4% |
| LDL-C, mg/dL | 1.002 | 0.998, 1.007 | 0.379 | 17.6% | 0.739 | 11.1% |
| HDL-C, mg/dL | 0.983 | 0.967, 1.000 | 0.050 | 17.8% | 0.521 | 12.6% |
| TG, mg/dL | 1.002 | 1.001, 1.003 | 0.012 | 17.3% | 0.707 | 5.0% |
| Lp(a), mg/dL | 1.003 | 0.997, 1.010 | 0.251 | 17.6% | 0.562 | 6.7% |
The results are presented as relative risks (RRs) with their 95% confidence intervals (CIs), as derived from multivariate Cox proportional hazard models
All models were adjusted for age, sex, body mass index, smoking status, MedDietScore, physical activity level, presence of hypercholesterolemia, hypertension and diabetes mellitus at baseline, use of lipid-lowering medication, and family history of cardiovascular disease
cNRI Continuous net reclassification improvement, CVD Cardiovascular disease, HDL-C High-density lipoprotein cholesterol, LDL-C Low-density lipoprotein cholesterol; Lp(a) Lipoprotein(a), TC Total cholesterol, TG Triglycerides