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. 2022 Dec 17;17:83. doi: 10.1186/s13024-022-00589-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The microglia subtype EADAM is observed in the Tau4RΔK-AP mice in the 6-month-old cortex. A UMAP plot showing microglia clusters—Homeostatic, DAM, and EADAM, across 4 genotypes in 6-month-old cortex (n = 3/genotype), and pie graphs showing the distribution of 3 microglia clusters across genotypes (n = 3/genotype). B Violin plots showing top cluster genes of 3 microglia clusters. C Bar graphs showing the distribution of 3 microglia clusters within each genotype (n = 3/genotype). Note the significant increase in the EADAM cluster in Tau4RΔK-AP mice. D Regulon analysis with SCENIC [40], showing key regulons in each microglia cluster. E GO analysis of top differential genes reveals a biological function in each microglial cluster. F UMAP plots of 7-month-old 5XFAD mice in Zhou et al. 2020 [23] (top) and a small cluster of cells (red circle) expressing a few EADAM-enriched markers (bottom). G Heatmap showing expression of EADAM-enriched genes across genotypes. * P < 0.05, ** P < 0.005, *** P < 0.0001