Table 2.
The tumour characteristics in the included studies
| First author | Year | Neoadjuvant chemotherapy | The size of the metastasesa | The number of the metastasesa | ||||
|---|---|---|---|---|---|---|---|---|
| Simultaneous resection | Staged resection | Simultaneous resection | Staged resection | Simultaneous resection | Staged resection | |||
| Valdimarsson | 2020 | 101 (63.13%) | 274 (72.68%) | 20 (12–30) mm | 20 (14–35) mm | 2 (1–4) | 2 (1–4) | |
| Kaibori | 2010 | / | 17 (40.48%) | / | / | 1: 2: 3 (4: 20: 8) | 1: 2: 3 (9: 11: 22) | |
| Le Souder | 2018 | / | / | 2 (1–3) cm | 3 (2–6) cm | 4 (2–8) | 3 (1–4) | |
| Luo | 2010 | 51 (39.53%) | 169 (61.23%) | < 5 cm: ≥ 5 cm (76: 53) | < 5 cm: ≥ 5 cm (153: 123) | 1: > 1 (81: 48) | 1: > 1 (97: 179) | |
| Martin | 2009 | 22 (31.43%) | 130 (81.25%) | 3.7 (0.3–8.8) cm | 4 (0.8–13.0) cm | 3 (1–16) | 3 (1–8) | |
| Martin | 2003 | / | / | ≤ 5 cm: > 5 cm (103: 31) | ≤ 5 cm: > 5 cm (65: 41) | 1: > 1 (81: 53) | 1: > 1 (42: 64) | |
| Moug | 2010 | / | / | / | / | / | / | |
| She | 2014 | 4 (14.29%) | 28 (31.82%) | 3.25 (1–20) cm | 3.25 (0.8–21) cm | 2 (1–multiple) | 2 (1–multiple) | |
| Thelen | 2007 | / | / | ≤ 50 mm: > 50 mm (24: 16) | ≤ 50 mm: > 50 mm (101: 78) | 1–3: ≥ 4 (34: 6) | 1–3: ≥ 4 (122: 57) | |
| Tsilimigras | 2021 | 80 (25.48%) | 130 (34.30%) | 2.5 (1.5–4.1) cm | 3.0 (1.9–4.8) cm | 2 (1–3) | 2 (1–4) | |
| Turrini | 2007 | / | / | / | / | < 4: > 4 (42: 15) | < 4: > 4 (27: 35) | |
| Weber | 2003 | / | / | ≤ 5 cm: > 5 cm (25: 10) | ≤ 5 cm: > 5 cm (38: 24) | 1–3: ≥ 4 (29: 6) | 1–3: ≥ 4 (39: 23) | |
| Yan | 2007 | / | / | 3.8 ± 3.4 cm | 5.9 ± 3.8 cm | 4 ± 2 | 3 ± 2 | |
| Vassiliou | 2007 | / | / | / | / | / | / | |
| de Haas | 2010 | 8(30.77%) | 24(92.31%) | 38 ± 33 mm | 41 ± 21 mm |
1: 2–3: > 3 (15: 7: 4) |
1: 2–3: > 3 (15: 7: 4) | |
| Boudjema | 2020 | 24 (61.54%) | 28 (60.87%) | 40.8 ± 28.8 mm | 37.2 ± 33.5 mm | 2 (1–13) | 2 (1–9) | |
| Kye | 2019 | 26 (18.18%) | 35 (53.85%) | 2.8 ± 1.9 cm | 2.7 ± 2.1 cm | 1.6 ± 1.1 | 2.4 ± 2.0 | |
| Abbott | 2012 | 46 (76.67%) | 52 (61.90%) | / | / | ≤ 5: > 5 (55: 5) | ≤ 5: > 5 (57: 27) | |
| Capussotti | 2006 | 3 (9.68%) | 38 (79.17%) | 5.5 (2.5–20) cm | 5 (0.6–14) cm | 1: 2: 3: 4: ≥ 5 (15: 5: 3: 4: 4) | 1: 2: 3: 4: ≥ 5 (13: 12: 7: 6: 10) | |
| Chua | 2004 | / | / | 3.7 ± 3.4 cm | 3.9 ± 2.8 cm | 2.5 ± 2.6 | 3 ± 2.2 | |
| Wu | 2022 | 213(43.03%) | 202(40.81%) | / | / | / | / | |
| Thongkan | 2020 | 8(38.10%) | 84(93.33%) | 40.1 (7.0–160.0) mm | 41.5 (8.0–165.0) mm | 2.4 (1.0–11.0) | 2.4 (1.0–10.0) | |
| Karam | 2022 | 19(86.36%) | 17(77.27%) | 24 (16–41) mm | 20 (10–39) mm | 5 (3–6) | 3 (2–6) | |
| Pooled differences (95% CI) |
0.33(0.19–0.56) P < 0.001 |
–0.10 (− 0.23 to 0.03) P = 0.123 |
0.17 (− 0.25 to 0.58) P = 0.437 |
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| First author | Unilobar distribution | Bilobar distribution | Major resection | Minor resection | ||||
|---|---|---|---|---|---|---|---|---|
| Simultaneous resection | Staged resection | Simultaneous resection | Staged resection | Simultaneous resection | Staged resection | Simultaneous resection | Staged resection | |
| Valdimarsson | / | / | / | / | 25 (15.63%) | 152 (40.32%) | 135 (84.37%) | 222 (59.68%) |
| Kaibori | 25 (78.13%) | 22 (52.38%) | 7 (21.88%) | 20 (47.62%) | / | / | / | / |
| Le Souder | 11 (42.31%) | 13 (48.15%) | 15 (57.69%) | 14 (51.85%) | 12 (46.15%) | 12 (44.44%) | 14 (53.85%) | 15 (55.56%) |
| Luo | / | / | / | / | 44 (34.11%) | 133(48.19%) | 85(65.89%) | 143(51.81%) |
| Martin | / | / | / | / | / | / | / | / |
| Martin | / | / | / | / | / | / | / | / |
| Moug | / | / | / | / | / | / | / | / |
| She | / | / | 8 (28.57%) | 24 (27.27%) | 12(42.86%) | 54(61.36%) | 16(57.14%) | 34(38.64%) |
| Thelen | 25 (62.50%) | 91 (50.84%) | 15 (37.50%) | 88 (49.16%) | 15 (37.50%) | 142 (79.33%) | 25 (62.50%) | 37 (20.67%) |
| Tsilimigras | / | / | / | / | 61(19.43%) | 164(43.27%) | 253(80.57%) | 212(55.94%) |
| Turrini | 43 (75.44%) | 25 (40.32%) | 14 (24.56%) | 37 (59.68%) | / | / | / | / |
| Weber | 27 (77.14%) | 20 (32.26%) | 8 (22.86%) | 42 (67.74%) | 11 (31.43%) | 35 (56.45%) | 24 (68.57%) | 27 (43.55%) |
| Yan | 23 (31.51%) | 20 (66.67%) | 50 (68.49%) | 10 (33.33%) | / | / | / | / |
| Vassiliou | / | / | 5 (20.00%) | 17 (21.79%) | 7 (28.00%) | 23 (29.49%) | 18 (72.00%) | 55 (70.51%) |
| de Haas | 19 (73.08%) | 19 (73.08%) | 7 (26.92%) | 7 (26.92%) | / | / | / | / |
| Boudjema | 23 (58.97%) | 27 (58.70%) | 16 (41.03%) | 19 (41.30%) | / | / | / | / |
| Kye | / | / | / | / | / | / | / | / |
| Abbott | / | / | / | / | 20 (33.33%) | 63 (75.00%) | 40 (66.67%) | 21 (25.00%) |
| Capussotti | / | / | 10 (32.26%) | 18 (37.50%) | / | / | / | / |
| Chua | 32 (50.00%) | 11 (34.38%) | 32 (50.00%) | 21 (65.63%) | / | / | / | / |
| Wu | 307 (62.02%) | 294 (59.39%) | 188 (37.98%) | 201 (40.61%) | 99 (20.00%) | 106 (21.41%) | 396 (80.00%) | 389 (78.59%) |
| Thongkan | / | / | 2 (9.52%) | 19 (21.11%) | ||||
| Karam | / | / | 9(40.91%) | 13(59.09%) | 2(9.09%) | 1(4.55%) | 20 (90.91%) | 21 (95.45%) |
|
1.52 (0.90–2.58) P = 0.117 |
0.69 (0.46–1.03) P = 0.070 |
0.43 (0.29–0.64) P < 0.001 |
2.34 (1.53–3.58) P < 0.001 |
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