Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 19;10:234. doi: 10.1186/s40168-022-01397-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 2 — RNA-seq analysis unravels ZEN-induced toxicity on the reproductive system. a–i ZEN disturbs the reproductive system (e.g., uterus) in pigs during phase 1/2. a Distribution of differentially expressed genes (DEGs) in the uterus of phase-1/2’s pig between the Ctrl group and ZEN group (n=4). b Gene Ontology (GO) classification of overlapping DEGs. BP represents biological process; CC represents cellular component; MF represents molecular function. c Top10 terms of GO enrichment of overlapping DEGs in the uterus of phase-1 pig, the heatmap of DEGs enriched in marked terms and MGI & Human diseases of representative DEGs. d Statistical analysis of top30 KEGG pathways enriched by DEGs in the uterus. e Pathways related to immune diseases and system in top30 KEGG pathways in the uterus of phase-1 (upper) or phase-2 (down) pig. The arrow referred to different terms between phase-1 pigs and phase-2 pigs. f, g Interactions of genes enriched in immune diseases and system terms in the uterus of phase-1 pigs (f) and phase-2 (g) pigs. h The heatmap of inflammatory cytokines in the uterus of phase-1 and phase-2 pigs based on interactions of genes enriched in immune diseases and system terms. i RPKM value and RT-qPCR results of representative genes detected in the uterus. Bar values are means ± SEM. *P < 0.05