Table 5.

Compositional data, intake values (calculated for chickens for fattening at 15 mg/kg complete feed), reference points and margin of exposure (MOE) for the individual components of cumin oil classified according to assessment groups

Essential oil composition			Exposure		Hazard characterisation		Risk characterisation
Assessment group	FLAVIS‐No	Highest conc. in the oil	Highest feed conc.	Intake (a)	Cramer Class (b)	NOAEL (c)	MOE	MOET
Constituent	–	%	mg/kg	mg/kg bw per day	–	mg/kg bw per day	–	–
CG 6
2‐(4‐Methylphenyl)propan‐2‐ol	02.042	0.31	0.047	0.0042	I	3	714
Carotol	–	0.20	0.029	0.0026	I	3	1,142
1,8‐p‐Menthadien‐4‐ol	–	0.07	0.011	0.0010	I	3	3,052
								381
CG 7
1,3‐p‐Menthadien‐7‐al	05.133	10.93	1.640	0.1472	(I)	34	231
1,4‐p‐Menthadien‐7‐al	–	6.66	0.999	0.0897	(I)	34	379
3‐p‐Menthen‐7‐al	–	0.93	0.140	0.0125	(I)	34	2,715
1,4‐p‐Menthanedien‐7‐ol	–	0.37	0.056	0.0050	(I)	34	6,806
Phellandral	–	0.28	0.042	0.0038	(I)	34	9,017
p‐Menth‐4(8)‐en‐7‐ol	–	0.08	0.012	0.0011	(I)	34	30,791
								131
CG 8
Carvotan acetone	–	0.40	0.060	0.0054	II	0.91	169
p‐Mentha‐1(7),5‐dien‐2‐ol	–	0.16	0.024	0.0022	I	3	1,375
Fenchone	02.016	0.05	0.008	0.0007	II	0.91	1,300
Carvenone	–	0.05	0.008	0.0007	II	0.91	1,275
Pinocarveol	02.100	0.04	0.006	0.0006	I	3	5,181
								191
CG 16
1,8‐Cineole	03.001	0.16	0.024	0.0022	(II)	100	46,414
CG 23
Cuminaldehyde	05.022	34.3	5.145	0.4619	(I)	200 (d)	433
4‐Isopropylbenzyl alcohol	02.039	0.82	0.123	0.0110	(I)	400	36,269
								428
CG 25
Carvacrol	04.031	0.33	0.050	0.0045	(I)	25	5,592
4‐Isopropylphenol	04.073	0.10	0.015	0.0013	(I)	25	18,944
Thymol	04.006	0.06	0.009	0.0008	(I)	25	30,942
								3,550
CG 31, II (Acyclic alkanes)
Myrcene	01.008	0.74	0.111	0.0099	(I)	44	4,434
β‐Farnesene	01.041	0.28	0.042	0.0037	(I)	44	11,796
MOET CG 31, II								3,222
CG 31, III (Cyclohexene hydrocarbons)
γ‐Terpinene	01.020	22.70	3.405	0.3057	(I)	250	818
α‐Phellandrene	01.006	1.14	0.171	0.0154	(I)	250	16,285
Limonene	01.001	0.52	0.079	0.0071	(I)	250	35,430
MOET CG 31, III								762
CG 31, IVe (Benzene hydrocarbons, alkyl)
p‐Cymene	01.002	18.8	2.820	0.2532	(I)	154	608
4‐Isopropenyl‐4‐methylbenzene	01.010	0.41	0.061	0.0055	I	3	545
								288
CG 31, V (Bi‐, tricyclic, non aromatic hydrocarbons)
α‐Pinene	01.004	12.70	1.905	0.1710	(I)	222	1,298
β‐Acoradiene	–	3.34	0.501	0.0450	(I)	222	4,936
β‐Pinene	01.003	1.07	0.161	0.0144	(I)	222	15,408
α‐Neocallitropsene	–	0.44	0.066	0.0059	(I)	222	37,468
Sabinene	01.059	0.39	0.059	0.0053	(I)	222	42,056
α‐Thujene	–	0.34	0.051	0.0046	(I)	222	48,631
MOET CG 31, V								887
CG 31, VI (macrocyclic non aromatic hydrocarbons)
3,7,10‐Humulatriene	01.043	0.06	0.008	0.0008	I	3	3,978

^(a)Intake calculations for the individual components are based on the use level of 15 mg/kg in feed for chickens for fattening, the species with the highest ratio of feed intake/body weight. The MOE for each component is calculated as the ratio of the reference point (NOAEL) to the intake. The combined margin of exposure (MOET) is calculated for each assessment group as the reciprocal of the sum of the reciprocals of the MOE of the individual substances.

^(b)When a NOAEL value is available or read‐across is applied, the allocation to the Cramer class is put into parentheses.

^(c)Values in bold refer to those components for which the NOAEL value was available, values in italics are the 5th percentile of the distribution of NOAELs of the corresponding Cramer Class, other values (plain text) are NOAELs extrapolated by using read‐across.

^(d)The NOAEL of 400 mg/kg bw per day for cumin alcohol was halved to take into account the higher reactivity of the aldehyde and the uncertainty in the read‐across.