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. 2021 Nov 17;12(2):388–401. doi: 10.1158/2159-8290.CD-21-0410

Figure 1.

Figure 1. Schematic of the design for the functional precision systems medicine study. The diagram illustrates how functional molecular precision systems medicine integrates high-throughput drug response assay and molecular profiling, aiming at individualized clinical translation of data for patients with AML. The n = 1 cycle on the left illustrates prospective real-time clinical translation through an FPMTB approach. The drug response and sequencing data are analyzed and integrated within a patient with a goal to tailor therapies in a realistic time frame. The n = many cycle on the right illustrates the data integration across a large sample set. The main goal here is to find possible biomarkers of drug responses, which eventually could also help to refine the rules of the FPMTB.

Schematic of the design for the functional precision systems medicine study. The diagram illustrates how functional molecular precision systems medicine integrates high-throughput drug response assay and molecular profiling, aiming at individualized clinical translation of data for patients with AML. The n = 1 cycle on the left illustrates prospective real-time clinical translation through an FPMTB approach. The drug response and sequencing data are analyzed and integrated within a patient with a goal to tailor therapies in a realistic time frame. The n = many cycle on the right illustrates the data integration across a large sample set. The main goal here is to find possible biomarkers of drug responses, which eventually could also help to refine the rules of the FPMTB.