Skip to main content
. Author manuscript; available in PMC: 2022 Dec 19.
Published in final edited form as: SLAS Discov. 2022 Oct 7;27(8):448–459. doi: 10.1016/j.slasd.2022.09.005

Fig. 9. NMDAR potentiation by CRF and blockade by CRFBP-CRF2 NAMs.

Fig. 9.

(A) CRF potentiated NMDA receptor EPSCs recorded from VTA-DA neurons (n = 8, 11). 30 μM of (B) MLS-0046818 (n = 4, 9) and (C) MLS-0219419 (n = 4, 8) block CRF potentiation of NMDAR EPSCs. (D) Summary of the M EPSC ± SEM. The asterisk indicates significant differences between treatment and vehicle samples (** p < 0.01), (n = mice, cells). Traces: Black, pre-CRF; Red, Post-CRF; Scale bar 25pA/ 25msec.