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. Author manuscript; available in PMC: 2022 Dec 19.
Published in final edited form as: SLAS Discov. 2022 Oct 7;27(8):448–459. doi: 10.1016/j.slasd.2022.09.005

Table 2.

Pharmacokinetic parameters for CRFBP-CRF2 NAMs.

PK Parameter MLS-0046818 MLS-0219419
t1/2 0.49 h 6.17 h
Tmax 0.25 h 0.25 h
Cmax 2.633 μM 0.797 μM
AUC0-t 1.580 μmol/L*h 5.798 μmol/L*h