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. Author manuscript; available in PMC: 2022 Dec 19.
Published in final edited form as: Sci Signal. 2020 May 5;13(630):eaaz1854. doi: 10.1126/scisignal.aaz1854

Fig. 7. Proposed model of Hsp90 regulation of opioid signaling in the spinal cord.

Fig. 7.

Our data suggest that phosphorylation of ERK-MAPK proteins in the spinal cord by the MOR in response to opioids is blocked by Hsp90. Thus, Hsp90 inhibition (by 17-AAG or KU-32) enables ERK MAPK phosphorylation by the MOR with opioid treatment, leading to an ERK-RSK-translation cascade that promotes opioid antinociception.