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. 2022 Dec 19;7:169. doi: 10.1038/s41541-022-00580-z

Fig. 4. Cocktail or prime-boost of SARS-CoV-2 WT-S and BA1-S proteins completely protected mice from the lethal Delta variant challenge.

Fig. 4

Above immunized K18-hACE2-Tg mice or control mice injected with PBS plus adjuvants were challenged with the SARS-CoV-2 Delta variant (10,000 PFU/mouse) 30 days after the last immunization, and observed for survival (a–d) and body weight changes (e–h) for a period of 14 days after challenge. The data (in e–h) are expressed as mean ± s.e.m of five mice in each group. Statistical significance among different vaccination groups was analyzed using Ordinary one-way ANOVA. * (P < 0.05) and ** (P < 0.01) indicate significant differences between the WT-S and BA1-S (e), WT-S and WT-S/BA1-S cocktail (f), BA1-S and WT-S prime/BA1-S boost (g), as well as BA1-S and WT-S/BA1-S cocktail (h) groups.