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. 2022 Dec 19;23(1):28–30. doi: 10.1016/S1473-3099(22)00805-2

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Neutralisation of omicron subvariants by serum samples from individuals with delta and omicron subvariant breakthrough infections

Neutralisation of omicron subvariants, determined by 50% neutralisation titres, by 20 serum samples collected from individuals with delta breakthrough infections (A), 19 serum samples collected from individuals with BA.1 breakthrough infections (B), 15 serum samples collected from individuals with BA.2.2 breakthrough infections (C), 19 serum samples collected from individuals with BA.5.12 breakthrough infections (D), 17 serum samples collected from individuals with BA.2.76 breakthrough infections (E), and 16 serum samples collected from individuals with BF.7 breakthrough infections (F). The horizontal dotted line in all graphs represents a limit of detection of 30, and serum samples with a neutralisation of less than 30 are plotted as 10. The geomatic mean titres and the percentage of individuals with 50% neutralisation titres values above the limit of detection are shown at the bottom of the graph. The fold-change of the geometric mean titre is denoted in brackets. A two-tailed Friedman test with a false discovery rate for multiple comparisons was performed.

Neutralisation of omicron subvariants by serum samples from individuals with delta and omicron subvariant breakthrough infections

Neutralisation of omicron subvariants, determined by 50% neutralisation titres, by 20 serum samples collected from individuals with delta breakthrough infections (A), 19 serum samples collected from individuals with BA.1 breakthrough infections (B), 15 serum samples collected from individuals with BA.2.2 breakthrough infections (C), 19 serum samples collected from individuals with BA.5.12 breakthrough infections (D), 17 serum samples collected from individuals with BA.2.76 breakthrough infections (E), and 16 serum samples collected from individuals with BF.7 breakthrough infections (F). The horizontal dotted line in all graphs represents a limit of detection of 30, and serum samples with a neutralisation of less than 30 are plotted as 10. The geomatic mean titres and the percentage of individuals with 50% neutralisation titres values above the limit of detection are shown at the bottom of the graph. The fold-change of the geometric mean titre is denoted in brackets. A two-tailed Friedman test with a false discovery rate for multiple comparisons was performed.