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Cross talk between autophagy and the KEAP1-NRF2 pathway. Phosphorylated p62 possessing pSTGE has a high affinity for KEAP1, resulting in impaired ubiquitination and consequent stabilization of NRF2. Increased production of phosphorylated p62 disrupts the KEAP1-NRF2 interaction and sequesters KEAP1 to the autophagosome, resulting in the stabilization of NRF2.
