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. 2018 May 2;98(3):1169–1203. doi: 10.1152/physrev.00023.2017

FIGURE 18.

FIGURE 18.

Roles of NRF2 in carcinogenesis highlighting the importance of context. NRF2 activation is beneficial and deleterious for the cancer-bearing host, depending on the time (initiation, promotion, and metastasis) and place (cancer cells or microenvironment). MDSCs, myeloid-derived suppressor cells.