Table 4.
Demyelinating disease subtype patient characteristics.
| MOG antibody positive | AQP4 antibody positive | MS | MOG compared with MS | AQP4 compared with MS | |
|---|---|---|---|---|---|
| Subjects | 9 | 13 | 72 | ||
| Median age (Std) | 44 (11.4) | 49 (11.9) | 47 (14) | ||
| Number of females (%) | 7 (78) | 11 (85) | 61 (84) | ||
| ON by history, eyes (%) | 5 (28) | 9 (35) | 31 (22) | ||
| Optic neuropathy by criteria, eyes (%) | 8 (44) | 14 (54) | 52 (36) | ||
| Mean RNFL thickness (Std) µm N = 184 eyes |
77.3 (16.3) | 86.6 (22.9) | 91.0 (15.3) | †Δ = 1.42 p=0.68 |
†Δ = −3.39 p=0.23 |
| IOD RNFL thickness (Std) µm N = 92 subjects |
5.9 (5.3) | 16.6 (21.7) | 7.5 (8.8) | *Δ = −1.5 [2.71] p=0.58 |
*Δ = 8.94 [2.29] p<0.05 |
| Mean GCL+IPL thickness (Std) µm N = 184 eyes |
31.1 (6.1) | 30.7 (7.6) | 33.75 (9.9) | †Δ = −2.2 p=0.37 |
†Δ = −2.8 p=0.15 |
| IOD GCL+IPL thickness (Std) µm N = 92 subjets |
3.75 (3.9) | 3.4 (3.3) | 3.9 (4.4) | *Δ = −0.78 [1.59] p=0.63 |
*Δ = −0.81 [0.31] p=0.54 |
AQP4 = aquaporin 4; GCL+IPL = ganglion cell layer and inner plexiform layer; IOD = interocular difference; MOG = myelin associated glycoprotein; MS = multiple sclerosis; ON = optic neuritis; RNFL = retinal nerve fibre layer; Std = standard deviation.
*Correlation coefficient [standard error] for antibody status by linear regression model with age (centred and scaled), antibody status, and objective evidence of optic neuropathy (any), as covariates.
†Calculated by generalised estimating equations incorporating binocular retinal nerve fibre layer thickness results with age (centred and scaled), antibody status, objective evidence of optic neuropathy, and sex as covariates.