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. 2022 Dec 6;5(4):pbac028. doi: 10.1093/pcmedi/pbac028

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© The Author(s) 2022. Published by Oxford University Press on behalf of the West China School of Medicine & West China Hospital of Sichuan University.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — PDOs preserve histopathological features of original tissue. (A) Graphic abstract of experimental design; (B) Representative H&E staining images of ccRCC original tumors, together with light microscopy, H&E staining and enlarged images of corresponding PDOs; (C) Representative IHC staining images of matched original tumors and PDOs for CAIX, CD10, VIM, and CK7. PDOs, patient-derived organoids; H&E, hematoxylin and eosin; ccRCC, clear cell renal cell carcinoma; IHC, immunohistochemistry; CAIX, carbonic anhydrase IX; VIM, vimentin; CK7, cytokeratin.