Figure 3.

Inflammation and acute axonal injury in the anterior optic pathway. The association between microglial–macrophage inflammatory infiltrate and acute axonal injury β-APP in multiple sclerosis [active plaques (A–C); mixed active/inactive plaques (D–F); and non-lesional white matter (G–I)] and neuromyelitis spectrum disorder [active plaques (J–L); non-lesional white matter (M–O)]. We compared PLP (left column) with CD68+ elements (middle column) and β-APP positive axons (right column, some indicated by arrowheads). The asterisk on the PLP section indicates the site where the CD68 and β-APP images were acquired. Scale bar = 100 µm.