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Comparison of phenotypes of mice with global and PT deletion of Tmem27 relative to their respective control mice
| Hypertension | Augmented Salt Sensitivity | Endothelial Dysfunction | Decreased Renal Blood Flow | Increased Superoxide | Increased Na+/H+ Exchanger Isoform 3 Expression | Decreased Lithium Clearance | |
|---|---|---|---|---|---|---|---|
| Global collectrin knockout mice | + | + | + | + | + | + | + |
| PT collectrin knockout mice | + | − | − | − | + | + | + |
PT, proximal tubule.
