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. Author manuscript; available in PMC: 2022 Dec 19.
Published in final edited form as: Nature. 2021 Dec 15;601(7893):452–459. doi: 10.1038/s41586-021-04220-9

Extended Data Figure 9. Chemical structures for series of the SAR-by-catalog analogs of antagonists, discovered by V-SYNTHES.

Extended Data Figure 9.

Shown are 60 analogs of 523 (a), 610 (b), and 673 (c) with inhibitory activity >40% in the single point functional assays. All 104 analogs tested are shown in Supplementary Information Table S3.