Extended Data Figure 10. Functional potency and binding affinity assessment of the SAR-by-catalog analogs of the antagonist 523, discovered by V-SYNTHES.

Table compounds with CB₂ potency better than 500 nM are shown, antagonists with affinities better than 10 nM highlighted in bold, >50-fold selective by italic. Functional K_i values and 95% Confidence Intervals were calculated from n=4 independent assays with 16 dose-response points. Affinity Ki values and 95% Confidence Intervals were calculated from n=3 independent assays with 8 dose-response points.