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. Author manuscript; available in PMC: 2022 Dec 19.
Published in final edited form as: Nature. 2021 Dec 15;601(7893):452–459. doi: 10.1038/s41586-021-04220-9

Extended Data Figure 12. Assessment of off-target selectivity for the best SAR-by-catalog compounds 733 and 747.

Extended Data Figure 12.

(a-b) Screening of compounds 733 and 747 in GPCRome-Tango assay for >300 receptors at 10 μM concentrations. Dopamine D2 (DRD2) and 100 nM Quinpirole served as an assay control. The data are presented as mean ± SEM (n=4) and the values of fold of basal > 3 marked as significant hits. (c-d) Follow-up dose-response curves for targets with >3 fold increased activity. Known agonists that showed activity served as positive controls. The data were presented as mean ± SEM with n=3 independent experiments, each run carried out in triplicate.