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. Author manuscript; available in PMC: 2022 Dec 19.
Published in final edited form as: Nature. 2021 Dec 15;601(7893):452–459. doi: 10.1038/s41586-021-04220-9

Extended Data Figure 14. Experimental characterization of candidate ROCK1 inhibitors predicted by V-SYNTHES.

Extended Data Figure 14.

Full dose-response curves for the ROCK1 hits in (a) functional potency and (b) binding affinity at human ROCK1. The data points are presented as mean ± SEM from n=3 independent experiments, each run carried out in triplicate. (c) Values of binding affinities and functional potencies for all candidate compounds predicted by V-SYNTHES. Bold font highlight hits with IC80<10 μM. Estimated values for curves that did not allow accurate fitting are marked with *.