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. 2022 Sep 8;27(12):5124–5134. doi: 10.1038/s41380-022-01747-9

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

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Fig. 3 — a, b Dose-response relationship between LED intensity (20–100% maximum intensity; intervals of 20%) and NMDAR-mediated _UVEPSC amplitude in representative PV+ interneurons (−55 mV holding potential) in the absence (a) or presence (b) of D-AP5 (50 µM). c Dose-response relationship for each PV+ interneuron tested in the absence (gray; n = 29 neurons) or presence (purple; n = 8 neurons) of D-AP5. Points represent _UVEPSC amplitude at a given stimulus intensity for an individual PV+ interneuron. Lines represent the best fit of the dose-response measurement for each neuron determined by simple linear regression. d Summary of regression line slopes plotted in c. Slopes are steeper for PV+ interneurons in the absence (black; n = 29 neurons; −1.69 ± 0.24 pA/1% LED) compared to the presence of D-AP5 (purple; n = 8 neurons; −0.06 ± 0.02 pA/1% LED; U = 0; p < 0.001). Data represented as mean ± SEM. ***p < 0.001; Mann–Whitney test for unpaired comparisons (d).