Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep 8;27(12):5124–5134. doi: 10.1038/s41380-022-01747-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a Schematic of the experimental approach used to measure the contribution of PV+ interneuron NMDARs to thalamus-evoked FFI in layer 5/6 pyramidal neurons (0 mV holding potential) in acute coronal slices of adult mPFC. The effect of D-AP5 on IPSC amplitude was compared in mice with GluN1 expression intact (black; PV-WT::GluN1^fl/fl) or GluN1 knocked out (pink; PV-Cre::GluN1^fl/fl) from PV+ interneurons. b Representative recordings of feedforward IPSCs in slices from PV-WT::GluN1^fl/fl (left) or PV-Cre::GluN1^fl/fl conditional knockout (right) mice in aCSF (black or pink) and during application of 50 µM D-AP5 (gray). c Average time course of normalized feedforward IPSC amplitude in PV-WT::GluN1^fl/fl (black; n = 8) or PV-Cre::GluN1^fl/fl conditional knockouts (pink; n = 6) in response to D-AP5 application. d D-AP5 decreases feedforward IPSC amplitude more in PV-WT::GluN1^fl/fl (n = 8 neurons; 45.71 ± 7.0%) than in PV-Cre:: GluN1^fl/fl conditional knockouts (n = 6 neurons; 16.87 ± 2.37%; U = 0; p < 0.001). Group data (c, d) represented as mean ± SEM. ***p < 0.001; Mann–Whitney test for unpaired comparisons (d).