Fig. 2. Leptin enhances social reward-conditioned place preference under non-stressed conditions in adolescent male mice.

a Schematic diagram of the experimental design in saline control and leptin-injected (1.0 mg/kg) mice. Illustrations were created with BioRender.com. b Time spent in social bedding shown in individual mice. c Average time spent in the compartment with social bedding. d Normalized social preference. e Subtracted social preference. Saline treatment, n = 8 male mice; leptin treatment, n = 7 male mice. *P  <  0.05, **P  <  0.01, ***P  <  0.001 compared with pre-conditioning or saline-treated group.