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. 2022 Sep 22;27(12):4948–4958. doi: 10.1038/s41380-022-01778-2

Fig. 3. Leptin reverses chronic unpredictable stress (CUS)-induced social anhedonia in adolescent male mice.

Fig. 3

a Schematic diagram of the experimental design in saline control and leptin-injected (1.0 mg/kg) mice. Illustrations were created with BioRender.com. b Time spent in the compartment with social bedding. c Average time spent in the compartment with social bedding. d Normalized social preference. e Subtracted social preference. Saline treatment, n = 12 male mice; leptin treatment, n = 14 male mice. *P  <  0.05, **P  <  0.01 compared with pre-conditioning or saline-treated group; ns, no statistical significance.