Table 1.
Baseline characteristics
| Artemether–lumefantrine (n=738) | Multivitamin (n=742) | Total (n=1480) | ||
|---|---|---|---|---|
| Demographics | ||||
| Age, years | 29 (21–40) | 30 (21–40) | 30 (21–40) | |
| Sex | ||||
| Male | 546 (74%) | 589 (79%) | 1135 (77%) | |
| Female | 192 (26%) | 153 (21%) | 345 (23%) | |
| Weight, kg | 52 (7) | 52 (8) | 52 (7) | |
| Nationality | ||||
| Khmer | 737 (>99%) | 740 (>99%) | 1477 (>99%) | |
| Laos | 1 (<1%) | 2 (<1%) | 3 (<1%) | |
| Occupation | ||||
| Farmer | 706 (96%) | 712 (96%) | 1418 (96%) | |
| Student | 10 (1%) | 15 (2%) | 25 (2%) | |
| Soldier | 11 (1%) | 8 (1%) | 19 (1%) | |
| Teacher | 5 (<1%) | 3 (<1%) | 8 (<1%) | |
| Housewife | 3 (<1%) | 0 | 3 (<1%) | |
| Fishing | 1 (<1%) | 1 (<1%) | 2 (<1%) | |
| Village leader | 1 (<1%) | 1 (<1%) | 2 (<1%) | |
| Village malaria worker | 0 | 1 (<1%) | 1 (<1%) | |
| Seller | 0 | 1 (<1%) | 1 (<1%) | |
| Environment department | 1 (<1%) | 0 | 1 (<1%) | |
| Medical history* | ||||
| Previous malaria episodes | 427 (58%) | 421 (57%) | 848 (57%) | |
| Dengue fever | 0 | 1 (<1%) | 1 (<1%) | |
| Symptoms | ||||
| Headache | 30 (4%) | 26 (4%) | 56 (4%) | |
| Dizziness | 18 (2%) | 20 (3%) | 38 (3%) | |
| Abdominal pain | 9 (1%) | 14 (2%) | 23 (2%) | |
| Joint pain | 12 (2%) | 6 (1%) | 18 (1%) | |
| Fatigue | 4 (<1%) | 4 (<1%) | 8 (<1%) | |
| Muscle pain | 5 (<1%) | 2 (<1%) | 7 (<1%) | |
| Diarrhoea | 4 (<1%) | 1 (<1%) | 5 (<1%) | |
| Itching or rash | 1 (<1%) | 2 (<1%) | 3 (<1%) | |
| Nausea | 0 | 1 (<1%) | 1 (<1%) | |
| Vomiting | 0 | 1 (<1%) | 1 (<1%) | |
| Physical examination | ||||
| Tympanic temperature†, °C | 36·6 (0·4) | 36·5 (0·4) | 36·6 (0·4) | |
| Movement abnormality | 0 | 0 | 0 | |
| Skin abnormality | 0 | 0 | 0 | |
| Eye abnormality | 0 | 0 | 0 | |
| Breathing abnormality | 0 | 0 | 0 | |
| Speech abnormality | 0 | 0 | 0 | |
| Hearing abnormality | 0 | 0 | 0 | |
Data are median (IQR), n (%), or mean (SD).
*
History within previous 5 years.
†
At screening.