Table 5.

Cox regression analysis: the effect of CPAP on MACEs in patients with moderate–severe OSA by clusters (n=1108)

	Cluster 1	Cluster 2	Cluster 3	Cluster 4
No. of subjects	333	265	271	239
Incident MACEs, n (%)	57 (17.1%)	38 (14.3%)	46 (17.0%)	43 (18.0%)
Crude HR	0.49 (0.25 to 0.95)	0.85 (0.33 to 2.19)	0.94 (0.45 to 1.95)	1.18 (0.62 to 2.27)
Adjusted HR*	0.44 (0.22 to 0.85)	0.85 (0.33 to 2.19)	0.85 (0.41 to 1.77)	1.57 (0.79 to 3.13)
Adjusted HR†	0.45 (0.23 to 0.90)	0.79 (0.30 to 2.12)	0.68 (0.31 to 1.45)	1.40 (0.67 to 2.91)

*Adjusted for age, gender and body mass index.

†Adjusted for age, gender, body mass index, waist circumference, neck circumference, AHI, TST90 and mean heart rate.

AHI, apnoea–hypopnoea index; MACEs, major adverse cardiovascular events; OSA, obstructive sleep apnoea; TST90, sleep time with oxygen saturation below 90%.