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. 2022 Mar 31;72(1):153–167. doi: 10.1136/gutjnl-2021-325915

Figure 3.

Figure 3

Immunological features of CD4+ T-cell subsets and interaction with CD8+ T cells. (A) The UMAP plots of CD4+ T-cell subsets. (B) PAGA analysis showing the potential developmental connectivity between different CD4+ T-cell subsets. (C) RNA velocity analysis showing the transition potential among CD4+ T-cell subsets. (D) The UMAP plots of CD4+ T-cell subsets showing tissue distribution. (E) Tissue prevalence of CD4+ T-cell subsets estimated by Ro/e score. (F) The UMAP plots of CD4+ T-cell subsets showing stage distribution. (G) Box plots showing the proportions of CXCL13+ CD4+ T cells in liver CD4+ T cells across stages. One-sided unpaired Wilcoxon test. (H) Box plots showing the proportions and violin plots showing the regulatory scores of liver-resident Treg cells across stages. One-sided unpaired Wilcoxon test. AR, acute recovery; CR, chronic resolved; HC, healthy control; IA, immune active; IT, immune tolerant; PAGA, partition-based graph abstraction; Treg, regulatory T-cell; UMAP, uniform manifold approximation and projection.