Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 6;13:1015355. doi: 10.3389/fimmu.2022.1015355

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Wang, Yang and Song

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The concentration distribution of the key metabolites, GS-441524 and X1, in the liver, lungs, and blood in rats or mice. Oral VV116 administration can circumvent liver-targeting issues. (A) The concentration of ^[14C]GS-441524 in the liver, lungs, and blood following intravenous administration of ^[14C]remdesivir at a single dose of 10 mg/kg in male SD rats. (B) The concentration of ^[14C]GS-441524 in the liver, lungs, and blood following intravenous administration of ^[14C]remdesivir at a single dose of 10 mg/kg in male Long Evans rats. (C) The concentration of X1 in the liver, lungs, and blood following oral administration of VV116 at a single dose of 100 mg/kg in Balb/c mice. (D) The concentration of X1 in the liver, lungs, and blood following oral administration of VV116 at a single dose of 30 mg/kg in SD rats.